Steroids 101

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Steroids

Anabolic-androgenic steroids (AAS) are performance enhancing drugs (PEDs) that are structurally related to the cyclic steroid ring system and have similar effects to testosterone in the body. They increase protein within cells, especially in skeletal muscles. 



AAS were synthesized in the 1930s, and are now used therapeutically in medicine to stimulate bone growth and appetite, induce male puberty and treat chronic wasting conditions, such as cancer or AIDS. "Anabolic" refers to muscle building, "androgenic" refers to increased masculine characteristics, both of which occur with AAS use. 



Other beneficial effects include promoting strong bones and reducing inflammatory costs associated with over exercising every day stressors; unfortunately many side effects also accompany steroid use because they affect the HPTA (Hypothalamic-Pituitary-Testicular Axis) in negative ways.




Basically, AAS are used by performance enhancers to get more out of workouts and help build muscle faster than what would normally be achieved naturally. The problem with this is that the side effects can often outweigh the benefits when it comes to healthy individuals abusing steroids; however, for those who suffer from medical conditions that cause muscle wasting, health care professionals will prescribe these drugs so that patients can rebuild their strength while undergoing chemotherapy or other forms of therapy.



AAS work by binding to the androgen receptor (AR) in cells; the AR is a regulatory protein found inside skeletal muscles as well as many other organs in the body. When AAS bind to the AR, it causes an increase in protein synthesis within the cell, which results in increased muscle mass over time when combined with regular workouts.



Effects of steroids on men



It is true that steroids are used therapeutically to treat some medical conditions; however, performance enhancers abuse them for their powerful hypertrophic effects and ability to rapidly put on lean muscle mass. 



Most healthy adult males simply do not need to take them because they produce naturally high testosterone levels , enough to obtain large muscles unless they are actively trying not to bulk up. 



Steroids cause an increase in lean muscle mass but also have negative side effects that may make the risk worthwhile only for who desperately want or need extra strength and endurance.



Excess steroid use suppresses the natural production of testosterone in the body through negative feedback on the hypothalamic-pituitary axis (HPA). 



The HPA is a group of glands and other tissues in the brain that work together to control hormone levels in the human body. When androgen levels are high, it sends chemical signals to the HPA to reduce its output of GnRH (gonadotropin releasing hormone), LH (luteinizing hormone) and FSH (follicle stimulating hormone). 



This disruption greatly reduces sperm count, which ultimately leads to male infertility due to lack of gonadal stimulation by LH; because LH promotes spermatogenesis within testes , low LH also causes testicular atrophy (shrinking), which impairs or completely prevents the body's natural ability to produce testosterone.



Effects of steroids on women



Females are more sensitive to the anabolic effects of AAS than males; however, they also have much lower levels of androgens than men do to begin with. This is why it takes a relatively large amount of AAS for most women to see any measurable muscle growth, even if they take a low dosage relative to what a man would use. 



In fact, many female athletes opt not only for less harmful substances such as Clenbuterol , but avoid anabolics altogether because their bodies are simply not equipped with enough androgen receptors to be affected by these drugs in a positive way without encountering serious negative effects.



The problem with steroid use for women is that it can alter the natural hormonal balance of the body, which causes problems such as acne and excessive hair growth ( hirsutism ) and even contribute to conditions like polycystic ovarian syndrome (PCOS). Female athletes who abuse AAS often experience significant changes in their menstrual cycles because the drugs negatively affect the HPA; this causes estrogen levels to rise and testosterone levels to fall, disrupting ovulation and greatly reducing fertility (if not making it completely impossible). 



Other side effects of steroids may include clitoral enlargement, shrinking of the breasts and increased risk of breast cancer due to high concentrations of circulating estrogens.



Steroid risks for men



One common misconception about anabolic steroids is that they are essentially a 'miracle drug' for bulking up and packing on muscle mass. In reality, their use typically backfires to produce the opposite effect, as excessive AAS intake causes muscles to shrink due to a reduction in testosterone production. 



The excess steroids remain in the body despite being unneeded, which leads to distressing effects such as inflammation of the liver , jaundice (yellowish pigmentation of skin) and even severe acne outbreaks called "roid-rage."



In addition to negative side effects from long-term steroid use, athletes typically experience short-term problems such as sexual dysfunction , hair loss and lowered sperm count or infertility . These conditions often lead users who want have a family one day into turning to expensive and often ineffective treatments such as testosterone replacement therapy, which is far from ideal for male fertility .

Steroid risks [of side effects]



The unending list of possible negative steroid side effects typically leads to the conclusion that the risk of harm is not worth any potential benefit. However, there may be a way around this problem: we simply need to alter the anabolic steroid molecules themselves in order to create new compounds with similar properties but fewer side effects. Curiously enough, several AASs can already do just that; their counterparts do exist in nature and are used by the human body (albeit in very minute quantities), but they were found to cause little or no side effects when isolated and concentrated into supplements. 



After all, the hormone testosterone can effectively build muscle and enhance physical performance without causing acne, hair loss or even shrinking the testicles (a common side effect of traditional AASs like Dianabol).



The use of steroids is still highly controversial due to their potential negative effects; however, the development of selective androgen receptor modulators (SARMs) may be a step in the right direction. 



These drugs may not only target specific androgen receptors that cause beneficial gains such as increased strength and lean body mass, but they also do not affect organs such as the liver or blood pressure to a significant degree. In other words, more effective performance enhancers with reduced side effects are on the horizon – so watch this space.


Clenbuterol



Clenbuterol is definitely a drug that works on the sympathomimetics group and is employed in clinical treatment of asthma and also other lung diseases like COPD. If you go into its history, we can easily see that it was studied due to its bronchodilator effects in the middle 1960s by the scientists from the French pharmaceutical company Boehringer Ingelheim. But over 40 years ago, CLEN still did not become popular for fat reducing purposes.


Today, Clenbuterol has become one of the most well-known firming or dieting agents used across Europe and US. It really is extensively praised as an effective agent for helping people lose weight while preserving lean muscle mass gains at possible highest level.


There are many websites that give Clenbuterol HCL for weight loss, but nevertheless there is some room to learn more true information regarding how it really works.


For this reason our objective today becomes bringing the actual facts about its metabolism, effects on body fat burning mechanisms and also its results in terms of losing bodyweight. But before we show you any of that, let us go through some basics about what clenbuterol is all about - what type of drug it truly is and exactly why the various other term like 'speedy clen' or 'clen'.


Clenbuterol (or CLEN) can be a sympathomimetic which means it mimics adrenaline within the human body; this is the reason why we can easily call it as beta agonist. Clenbuterol (we'll keep on calling it as such) is a very strong bronchodilator that works for those people with breathing difficulties like COPD and asthma.


It is also recognized as a thermogenic drug; you will find those who claim that there are some parts of this drug which help in mobilizing fat cells and boosting body's temperature resulting in better usage of fats.


A few would even go so far to state that they've got seen its effect on their blood pressure – clenbuterol diet pills online . But we do not have concrete information about these claims, but our team thinks that anyone who has used this for weight-loss will not say no to it.


The thing which makes clenbuterol so popular among bodybuilders and athletes is its appetite suppressing characteristic. These are the people who use this drug for weight reduction; even if they do not end up burning more fat, they can at least lose some water weight with clenbuterol due to reduced food cravings.


Now that we've got talked about what clenbuterol truly is all about (and now that you know it's a bronchodilator), let us make an effort to discuss how it works in terms of dieting and losing Bodyweight .


Before we proceed towards our discussion over how exactly does Clen work, make sure you understand that whenever you find yourself taking Clenbuterol, you are taking a bronchodilator. It is that simple - the drug will help you breathe simpler and work better. You can find those who are having this medication for some other illnesses but then take Clen to assist them with their breathing disorder; it will work well too, simply because of its sympathomimetic effects (it mimics adrenaline).


BUT there's something else that makes clenbuterol unique – its thermogenic impacts. The body's temperature begins to rise due to increased metabolic rate which results in better usage of fats as power source. The great thing about the medication is that it does not need any conversion process so fat loss means pure fat loss without losing too much lean muscle mass. We've been speaking about how does clenbuterol work, let us make an effort to discuss what its effects may cause in terms of weight loss.


It's important to note here that clenbuterol is a stimulant drug and it works on the sympathomimetic nervous system just like other drugs such as ephedrine and over the counter cold medications (like Sudafed). All these medications function similarly while having mild differences in terms of their mechanisms. 


However, they all have something associated with common: they do not last long. Even though you can find those drugs that come with longer half-life but this particular effect defeats our purpose because we wish to use these fat burning agents at certain intervals so they burn more fat second after second.


Clenbuterol's half-life is short, which means its effects will fade with time and you need to constantly take it if you wish to maintain the results. And this is exactly how it becomes useless – taking a drug all time is not what you would want right?


And this gets us precisely where we wanted – "How does clenbuterol work?". It has its sympathomimetic and thermogenic properties that contribute towards losing bodyweight. The drug stimulates the heart and raises the rate of metabolism because of which there are more calories burned within but beyond that, it also suppresses appetite which ultimately results in less food ingestion while sporting activities burn additional fat due to improved oxygen intake.


Now let us get to the crux of your matter – "Is clenbuterol or clen effective and safe?".


The answer is that it does not cause any severe damage in most cases but one should take note that this medication may be dangerous for some people, especially those who have problems with cardiac muscles. Also, if you just got done with a lengthy illness and only recently (or even still) utilize medications, you need to ask your doctor before resorting to any such weight loss medication.


Another thing about Clenbuterol which we did not really mention above is its capability to raise blood pressure because of improved metabolic rate; however, higher energy levels do not necessarily mean more fat burn (you would find out why soon). If you notice any negative effects of blood pressure level hike, you must quit using clenbuterol immediately.


Even though the drug itself is considered to be safe for use by most athletes when taken in moderation but its long-term consequences are still unknown. Also, if one has problems with cardiac muscles, the medication should never be taken because it can prove fatal in such cases. Clenbuterol does not produce quick results so one should resort to using other medications that burn fat fast only under special circumstances. Planning on getting "shredded" before summer or something? Then Clenbuterol may come in extremely useful but remember that it will not produce overnight results and although its half life is short, it requires frequent cycles if you wish to maintain the weight loss.


Clenbuterol is a steroidal bronchodilator which was first synthesized in 1972 and approved for human use by FDA in 1990 as an asthma medication. Its main characteristic, besides its bronchodilating abilities, is that it as a thermogenic drug that stimulates both beta-2 and beta-3 receptors thus promoting lipolysis (breakdown of fat). Additionally, clen has the ability to antagonize alpha 2 receptors which leads to improved muscle growth and further increase in metabolic rate due to increased norepinephrine levels. This all results into more calories being burned without actual movement of muscles.


Clenbuterol is an accomplished known drug that has become highly known as a good weight loss producing drug. Clenbuterol was not actually developed as a diet drug. But it really is now well-established amidst those who make use of it as an extremely helpful weightloss accelerator. Clenbuterol for weight loss is something that needs to be discussed at great length.  


So let us get directly onto that can we? I am estimating by now you are here looking for information on whether or not its a beneficial idea to buy clenbuterol on the foundation that it may assist you shed some additional body mass and get rid of any unwanted extra weight, great? 


Well I mean my first off guess and the primary reason this article was written was due to the fact I want to write-up some clenbuterol experiences and help you if you choose to buy clenbuterol.


I am going to publish up several of my experience with clenbuterol also including the weight loss effects I had. And also any of the side effects. The upsides and the problems. How much clenbuterol may cost to buy, and the best place to buy clenbuterol. Places where never to buy clenbuterol and if you are UK based, where you can buy clenbuterol throughout the uk. 


The efficient fat burning properties of this steroid, frequently known as Clen, is it's hallmark. One of CLEN's features is it's ability to interact with the body's receptors used for releasing fat cells. After these fat cells are released, they can be used as fuel - for weight loss as well as energy. It should also be noted that Clen for sale online is in use on livestock worldwide by veterinarians - specifically as a bronchodilator.


In the past, the use of CLEN on animals was to produce meat with less fat. This practice is now forbidden in a lot of countries, even though some countries still use CLEN for this purpose. However, this substance is not sanctioned or approved for use within the US by veterinarians. In the sports community, Clenbuterol, however, continues to be sought after.

Sustanon v Sustanon 250


Sustanon is literally an oil-based injectable containing four various testosterone ingredients: testosterone propionate, 30 milligram; testosterone phenylpropionate, 60 milligrams; testosterone isocaproate, 60mg; and also testosterone decanoate, 100 mg. The mixture of the testosterone are time circulated to allow an instantaneous influence while still remaining proactive inside the body for up to 1 month. 


Just like various other testosterones, Sustanon is definitely an androgenic steroid using a pronounced anabolic effect. Subsequently, people continuously use Sustanon to put on bulk and size while increasing endurance. However dissimilar other testosterone compounds for example cypionate as well as enanthate, the usage Sustanon results in not so much water holding and estrogenic adverse side effects.


This characteristic is extremely beneficial to body builders who are suffering from gynecomastia but still seek the effective anabolic impact of a injectable testosterone. The decreased liquid retention also makes Sustanon an attractive steroid for weight lifters and sports athletes interested in a cutting cycle up or getting a solid foundation of top quality weight. 


Dosages of Sustanon range from 250 milligrams every other week, up to 2000 mg or higher weekly. These doses seem to be the extremes. A prevalent dose would range from 250 mg to 1000 mg a week. Even though Sustanon stays active for approximately a month, injections must be taken at least once per week to keep testosterone amounts stable. 


To get the same effects on the body as testosterone - bigger muscles and less fat - the steroid to use is Sustanon. People explain the action of this steroid by saying that the muscles absorb more protein when this steroid is taken. Protein, as most people know, is the building block of muscle. Have you noticed that the muscle mass of body builders looks different? Have you wondered why? Here's the easy answer! 


Steroids, including Sustanon, cause the muscle mass to have a larger amount of muscle fiber. Consequently, the muscles will be bigger, and they will look different. Another desirable benefit is that the red blood cell count will go up. This helps somewhat with endurance and, afterwards, with recovery.


The difference between Sustanon and Sustanon 250 lies in the total number of milligrams each compound contains. A full description of both compounds should be detailed enough for one to understand which option is right for them.


The two compounds are identical in every other way, including half-life and release pattern. This article will provide insight into the differences that exist between these two compounds.


::: What's best? :::


Although both propionate and phenylpropionate esters were once commonly used, it has since been noted that they're not very compatible with intramuscular injection (IM). Because of this, the shorter acting decanoate ester was developed because it could be injected deeper (into muscle) and at a constant rate, reducing the chance of it being released too soon before reaching the target tissue.

Another advantage of this is that less frequent injections can be used since they provide a steadier release pattern than propionate or phenylpropionate esters. Of course, this depends on how often someone would like to inject.


::: Half-life :::


The half-life for any given ester increases as the ester itself gets larger. For example, testosterone enanthate has half-life of 7 days, while testosterone cipionate's half-life is only about 3 days! Because Sustanon 250 consists mainly of long acting testosterones with decanoate and undecanoate esters, it has a very long half-life compared to other testosterone compounds.


::: How do we use Sustanon? :::


Sustanon is injected once every 1-2 weeks at a dosage of 250mg/week for male patients, and 50-100mg/week for female patients. If the patient wishes to gain muscle as fast as possible, they can increase the frequency to as much as three times per week; however, this should only be done if their body can handle such frequent injections.

It's important not to mix up different testosterone compounds because the release pattern and half-life will be totally different from one compound to another (and you'll likely encounter problems). Also, always remember to use a new needle each time you inject, whether it's Sustanon or any other compound.


::: What is Sustanon 250? :::


Sustanon 250 consists of four esters which are testosterone propionate (30mg), phenylpropionate (60mg), isocaproate (60mg) and decanoate (100mg). It provides steady yet fast release of the testosterone esters into the blood stream with maximum peak levels reached between days 7-12. The total duration of action for this product is 2-3 weeks with an active life of 5-6 days.


:::: What about water retention? :::::


There will be very little water retention on Sustanon due to the propionate ester (which is also the shortest ester). Sustanon 250 will provide more water retention, but not at a level that would be considered excessive.


::: Which should I use? :::


As mentioned above, both products are identical in every other way; however, if one wanted to gain muscle as fast as possible without fearing too much about side-effects, they could opt for the shorter half-life of Sustanon 250. However, there may be some users who want to spread their injections out over three times per week because it can be inconvenient injecting so often. In this case it might be advisable to go with Sustanon since you wouldn't have to inject as frequently.


::: Conclusion :::


In conclusion, there is no clear-cut answer as to which product users should choose. Each individual will have a different preference that would be hard to judge without first considering the type of cycle they wish to run. Some may want longer half-life and others may want shorter action time; it's ultimately up to the user to decide which one they prefer. In any case, both products are very similar in their properties and effects with only a few subtle differences.  



Dianabol or DBol


Dianabol obtains its properties and capabilities with a methyl group element at carbon position 17-alpha. This is whats called C17 Alpha Alkylation, that permits the hormone to become bioavailable by mouth. 


Without this tweak of adding a methyl group inside of the 17th carbon position, the anabolic steroid would become swiftly dilapidated and prepared by the liver with very little chance to get to the blood stream to do its job. 


Dianabol is a very old anabolic steroid developed many decades ago. DBol is what this anabolic steroid is commonly called. Quite a few popular bodybuilders have gotten better results by combining testosterone with DBol. 


If you prefer taking a pill to getting an injection, you will have that choice with DBol. A major drawback to taking DBol is the problems it can cause for your liver. Another adverse effect is it will increase blood pressure.


Opinions have changed through the years as to what is the best dosage for DBol. Some people decide to take it exactly in the same amounts that well-known lifters have used in the past. 


But it is difficult to say that any dosage used for this purpose is safe. The androgenic reactions in the body can occur in many different areas. So it is helpful to understand more about the more androgenic influencing steroids.


Andriol

Some people become confused about Andriol, so we will discuss it here. It's an androgenic steroid that is often mistaken for an anabolic steroid. Research throughout the years has shown that Andriol does not cause a considerable difference when it comes to increased muscle mass or better fat loss. 


That there is nothing to be gained by the use of Andriol by performance athletes or bodybuilders is the consensus of opinion derived by past years of scientific study of this steroid. Furthermore, this readily-available steroid exhibits estrogenic effects due to the by-products produced during metabolism in addition to its progestational activity, making it inappropriate for male hormone replacement therapy.


Andriol (testosterone undecanoate) is a steroid indicated for treatment of adult males who have not responded to testosterone replacement therapy. It is available in capsules containing 40mg of micronized testosterone undecanoate.


Andriol is an orally active androgen that has been used for long term treatment of male hypogonadism with excellent results. In this article we will discuss the different indications, pharmacological profile and uses of Andriol in clinical practice. We will discuss its pharmacokinetics, drug interactions, efficacy, safety profile and a review a few case reports from our own experience as well as published literature .


Indications: Andriol (testosterone undecanoate) is a steroid indicated for treatment of adult males who have not responded to testosterone replacement therapy. It is available in capsules containing 40mg of micronized testosterone undecanoate.


Uses: Andriol (testosterone undecanoate) is indicated for the treatment of adult males who have not responded to treatment with testosterone alone. This analogue of testosterone has been used for long term treatment of male hypogonadism with excellent results.


Male hypogonadism occurs due to deficient production of normal amounts of testosterone, which can be treated with medications like Andriol 40/60 mg capsules1–3 months apart . It has also been used by performance athletes and bodybuilders seeking an alternative to injectable or orally active steroids4,5 since it offers an alternative mode of administration.


Pharmacokinetics: The pharmacological agent in Andriol is testosterone undecanoate, which is practically insoluble in water and hence it has to be used with a pharmaceutical oil carrier base .


Undecanoate esterification of the 17-β hydroxyl group confers lipophilicity on testosterone derivatives. The greater lipophilicity reduces first pass liver metabolism when compared with an ester like enanthate (Ravivar) which may result in improved bioavailability6–8% at peak levels; 90% in 10 hours; half life 36 - 40 hours9 Peak plasma concentrations are reached in 1-3hrs after oral administration10 Oral absorption occurs across the lipid membrane of the enterocytes followed by intracellular esterification.


After absorption, Andriol is quickly metabolised in liver and excreted in bile. The metabolites are then reabsorbed at lower rate in the small intestine12–14 A single oral dose of 40mg Andriol capsules has been found to result in plasma levels within normal range15 . Half life time has been shown to be 36 -40 hours.


Oral bioavailability has not yet been studied but it's likely around 4-6% due to common food substances that interfere with testosterone absorption16 Tmax is 1-3hrs.



Some people become confused about Andriol, so we will discuss it here. It's an androgenic steroid that is often mistaken for an anabolic steroid. Research throughout the years has shown that Andriol does not cause a considerable difference when it comes to increased muscle mass or better fat loss.


That there is nothing to be gained by the use of Andriol by performance athletes or bodybuilders is the consensus of opinion derived by past years of scientific study of this steroid. Furthermore, this readily-available steroid exhibits estrogenic effects due to the by-products produced during metabolism.


A male user of Andriol must take this drug in an amount sufficient to cause an estrogenic effect before this will become a problem. Most of the Anabolic Steroids used by athletes are taken either orally or by injection. With the latter form of administration, the shots are usually intramuscular or just under the skin.